壳聚糖
自愈水凝胶
肿胀 的
环糊精
化学
药物输送
膨胀能力
高分子化学
热重分析
傅里叶变换红外光谱
吸附
核化学
动态力学分析
糠醛
水溶液
化学工程
有机化学
催化作用
聚合物
工程类
作者
Mengke Zhang,Jinpeng Wang,Zhengyu Jin
标识
DOI:10.1016/j.ijbiomac.2018.03.106
摘要
Chitosan-cyclodextrin hydrogel (CFCD) was prepared via Diels-Alder reaction between furfural functionalized chitosan (CF) and N-maleoyl alanine functionalized hydroxypropyl β-cyclodextrin (HPCD-AMI) in aqueous media without any catalyst or initiator. The CF and HPCD-AMI were confirmed by Fourier transform infrared spectroscopy and 1H nuclear magnetic resonance spectroscopy. The resultant CFCD hydrogel was characterized in terms of thermal peripteries, microstructure, rheology behavior, and swelling capacity. The rheology analysis found that the storage modulus G′ ranged from 1 pa to 1200 pa as the degree of furfural substitute on chitosan increased from 2.6% to 28.3%, indicating the hydrogel strength can be tuned readily by reaction stoichiometry. The swelling behaviors proved that CFCD hydrogel was pH-responsive with low swelling capacity, which would be preferable for drug delivery. Drug adsorption analysis showed the introduction of cyclodextrin into CFCD hydrogels promoted drug adsorption capacity. In addition, methyl orange cumulative release in PBS buffer was only 48.85% after 24 h, suggesting CFCD hydrogel had good sustained release capacity on the loaded drug.
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