医学
优势比
孟德尔随机化
置信区间
冠状动脉疾病
内科学
全基因组关联研究
心脏病学
肺活量
单核苷酸多态性
肺
遗传学
肺功能
生物
基因型
扩散能力
基因
遗传变异
作者
Shiu Lun Au Yeung,Maria Carolina Borges,Debbie A. Lawlor
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:2018-04-01
卷期号:11 (4)
被引量:22
标识
DOI:10.1161/circgen.117.001952
摘要
Lung function, assessed by forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), is inversely associated with coronary artery disease (CAD), but these associations could be because of confounding or reversed causality. We conducted a 2-sample Mendelian randomization study, using publicly available data from relevant genome-wide association studies, to examine the role of FEV1 or FVC on CAD.We used the most recent genome-wide association studies on lung function to extract genetic instruments related to FEV1 and FVC (n=92 749). Data on the association between genetic instruments and CAD were obtained from Coronary Artery Disease Genome wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics 1000 Genomes-based genome-wide association studies (60 801 CAD cases and 123 504 controls). We used inverse-variance weighting with a multiplicative random effect to estimate the genetic instrumented association of FEV1 and FVC on CAD. Sensitivity analyses included weighted median and MR-Egger methods.Each SD greater FEV1 was associated with a lower risk of CAD (odds ratio, 0.78 per SD; 95% confidence interval, 0.62-0.98) with a similar magnitude for FVC on CAD risk (odds ratio, 0.82 per SD; 95% confidence interval, 0.64-1.06). Estimates for FEV1 were similar when using MR-Egger method (odds ratio, 0.80 per SD; 95% confidence interval, 0.33-1.94) although the magnitude was smaller for weighted median method (odds ratio, 0.93 per SD; 95% confidence interval, 0.75-1.17). Estimates for FVC in the sensitivity analyses were attenuated (median) or changed direction (MR-Egger).Our study suggested an inverse relation between FEV1 and CAD, but for FVC, evidence is less clear.
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