Catalytic Hetero-Diels-Alder Reaction of the Carbonyl Compounds

Background: The hetero-Diels-Alder (HDA) reaction is an important method for the construction of heterocyclic six-membered rings. The HDA reaction involving the carbonyl functionality as a dienophile or as a heterodiene makes dihydropyran ring accessible, which is present in many biologically active compounds. However, reactivity of the carbonyl group as a dienophile or as heterodiene is much less and for successful completion of the reaction, usually a catalyst is required. In view of this, there are always attempts afoot to devise more effective and specific catalysts for this purpose. Keywords: Hetero-Diels-Alder reactions, asymmetric Hetero-Diels-Alder reactions, carbonyl compounds, chiral catalysts, organocatalysts.