Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery

Background: Oral drug delivery is widespread owing to its non-invasive nature which complements high patient compliance. However, the drug administration via oral route is quite challenging due to the presence of the biochemical barriers which hinders the uptake as well as access to blood stream. Apart from that, stability, poor solubility and bioavailability of administered drug via the gastrointestinal (GI) tract are also exigent. Till now various oral formulations were developed which releases the drug in a timely manner but lacks appropriate therapeutic concentration. Keywords: Oral delivery, polymeric nanoparticles, lipid nanoparticles, biological barriers, bioavailability.