Diffusion tensor imaging of normal‐appearing white matter in patients with neuromyelitis optica spectrum disorder and multiple sclerosis

Background and purpose The occult changes in normal‐appearing white matter ( NAWM ) were investigated and compared amongst patients with neuromyelitis optica spectrum disorder ( NMOSD ), patients with multiple sclerosis ( MS ) and healthy controls ( HC s) by applying tract‐based spatial statistics to diffusion tensor imaging ( DTI ) data. Methods Diffusion tensor imaging was performed with a 3‐T scanner in 93 patients with NMOSD , 53 patients with MS and 43 HC s. Voxel‐wise statistical analyses of the DTI data were performed using tract‐based spatial statistics. Results Compared to HC s, patients with NMOSD had significantly lower mean global fractional anisotropy, higher mean diffusivity and radial diffusivity, and no significant differences in axial diffusivity in their NAWM . Patients with MS demonstrated significantly lower mean global fractional anisotropy and higher mean diffusivity, axial diffusivity and radial diffusivity in the NAWM than did patients with NMOSD and HC s. Compared to patients with NMOSD , patients with MS had NAWM damage that was more extensive, particularly in the inferior cerebellar peduncle, external capsule, cingulum, superior fronto‐occipital fasciculus and uncinate fasciculus. Conclusions Using DTI , widespread occult damage was demonstrated in the NAWM of patients with NMOSD . However, the NAWM was less affected in patients with NMOSD than it was in patients with MS ; specifically, the axonal injuries and diffusion abnormalities in the association fibers were more severe in patients with MS than they were in patients with NMOSD .