纳米载体
药物输送
材料科学
多重耐药
介孔二氧化硅
聚乙二醇
表面改性
纳米颗粒
纳米技术
介孔材料
毒品携带者
化学
核化学
有机化学
生物化学
物理化学
催化作用
抗生素
作者
Wei Cheng,Chaoyu Liang,Lv Xu,Liu Gan,Nansha Gao,Wei Tao,Lingyan Luo,Yixiong Zuo,Xusheng Wang,Xudong Zhang,Xiaowei Zeng,Lin Mei
出处
期刊:Small
[Wiley]
日期:2017-06-08
卷期号:13 (29)
被引量:215
标识
DOI:10.1002/smll.201700623
摘要
A nanocarrier system of d ‐a‐tocopheryl polyethylene glycol 1000 succinate (TPGS)‐functionalized polydopamine‐coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH‐responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug‐resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X‐ray photoelectron spectroscopy (XPS), Brunauer‐Emmett‐Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The normal A549 cells and drug‐resistant A549 cells are employed to access the cytotoxicity and cellular uptake of the NPs. The therapeutic effects of TPGS‐conjugated nanoparticles are evaluated in vitro and in vivo. Compared with free DOX and DOX‐loaded NPs without TPGS ligand modification, MSNs‐DOX@PDA‐TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy. This splendid drug delivery platform can also be sued to deliver other hydrophilic and hydrophobic drugs.
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