NAD+激酶
烟酰胺腺嘌呤二核苷酸
锡尔图因
代谢组
烟酰胺
烟酰胺磷酸核糖转移酶
生物化学
聚ADP核糖聚合酶
西妥因1
化学
生物
药理学
酶
代谢物
聚合酶
下调和上调
基因
作者
Daniel S. Matasic,Charles Brenner,Barry London
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2018-04-01
卷期号:314 (4): H839-H852
被引量:46
标识
DOI:10.1152/ajpheart.00409.2017
摘要
Nicotinamide adenine dinucleotide (NAD + ) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD + is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca 2+ signaling. Recent research has indicated that NAD + participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD + precursors, including nicotinamide riboside that boosts or repletes the NAD + metabolome, may be cardioprotective. This review examines the molecular physiology and preclinical data with respect to NAD + precursors in heart failure-related cardiac remodeling, ischemic-reperfusion injury, and arrhythmias. In addition, alternative NAD + -boosting strategies and potential systemic effects of NAD + supplementation with implications on cardiovascular health and disease are surveyed.
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