活性氧
氧化应激
类风湿性关节炎
细胞生物学
信号转导
细胞内
细胞信号
化学
生物
免疫学
生物化学
作者
Abdul Rehman Phull,Bakht Nasir,İhsan Ul Haq,Song Ja Kim
标识
DOI:10.1016/j.cbi.2017.12.024
摘要
There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of RA. Hence, understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for RA.
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