A study of the 15N NMR chemical shifts in substituted anilines and phenylhydrazines, and their derivatives

Abstract The analysis of 15 N chemical shift data from over a hundred anilines, N ‐methyl anilines, N , N ‐dimethyl anilines and phenylhydrazines with substituents in the phenyl ring leads to an empirical equation, δ cal = δon + Δ o + Δ m + Δ p , for calculating 15 N NMR chemical shifts of the amino group. This equation is based on a linear regression analysis using eighteen substituent parameters and leads to good conformity with the expected data. Copyright © 2008 John Wiley & Sons, Ltd.