戊二醛
化学
链酶
固定(群体遗传学)
结缔组织
生物物理学
渗透(战争)
高分子化学
生物化学
色谱法
胰蛋白酶
病理
生物
酶
工程类
基因
医学
运筹学
作者
David T. Cheung,Natasha Perelman,Ellen C. Ko,Marcel E. Nimni
标识
DOI:10.3109/03008208509152389
摘要
Bovine pericardium, a dense collagenous connective tissue, was crosslinked with glutaraldehyde using different modalities of fixation. The degree of crosslinking was evaluated as a function of the ability of CNBr and pronase to solubilize collagen. Our results suggest that glutaraldehyde fixes primarily the surface of the fibers and creates a polymeric network which hinders the further crosslinking of the interstitium of the fiber. When a low concentration of glutaraldehyde was used, a slow time-dependent crosslinking process was observed. This slow process is maintained over a long period of time, greatly beyond that required for the actual penetration of glutaraldehyde to occur.
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