Manicol, an aromatic sesquiterpene from Dulacia guianensis(Liriosma cf. acuta)

A eudesmane-type sesquiterpene acid with an aromatic A-ring isolated from a Guyanan tree Dulacia guianensis(Olacacea) was assigned a structure and an absolute stereochemistry (1) on the basis of spectroscopic evidence and partial synthesis. The isolate had moderate antileukaemic activity in P–388 lymphocytic leukaemia.