纳米医学
图书馆学
国家实验室
纳米技术
化学
政治学
医学
工程类
材料科学
计算机科学
工程物理
纳米颗粒
作者
Gang Liu,Ki Young Choi,Ashwinkumar Bhirde,Magdalena Swierczewska,Juan Juan Yin,Sang Wook Lee,Jae Hyung Park,Jong In Hong,Jin Xie,Gang Niu,Dale O. Kiesewetter,Seulki Lee,Xiaohong Chen
标识
DOI:10.1002/anie.201105565
摘要
Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a ZnII-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).
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