血管生成
兰克尔
骨重建
骨愈合
骨细胞
血管内皮生长因子
破骨细胞
皮质骨
软骨
骨关节炎
成骨细胞
生长因子
细胞生物学
医学
癌症研究
病理
化学
生物
内分泌学
内科学
解剖
受体
激活剂(遗传学)
替代医学
体外
血管内皮生长因子受体
生物化学
作者
Shek Man Chim,Jennifer Tickner,Siu Kei Chow,Vincent Kuek,Baosheng Guo,Ge Zhang,Vicki Rosen,Wendy N. Erber,Jiake Xu
标识
DOI:10.1016/j.cytogfr.2013.03.008
摘要
Angiogenesis plays an important role in physiological bone growth and remodeling, as well as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor metastasis to bone. Vascularization is required for bone remodeling along the endosteal surface of trabecular bone or Haversian canals within the cortical bone, as well as the homeostasis of the cartilage-subchondral bone interface. Angiogenic factors, produced by cells from a basic multicellular unit (BMU) within the bone remodeling compartment (BRC) regulate local endothelial cells and pericytes. In this review, we discuss the expression and function of angiogenic factors produced by osteoclasts, osteoblasts and osteocytes in the BMU and in the cartilage-subchondral bone interface. These include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), BMP7, receptor activator of NF-κB ligand (RANKL) and epidermal growth factor (EGF)-like family members. In addition, the expression of EGFL2, EGFL3, EGFL5, EGFL6, EGFL7, EGFL8 and EGFL9 has been recently identified in the bone local environment, giving important clues to their possible roles in angiogenesis. Understanding the role of angiogenic factors in the bone microenvironment may help to develop novel therapeutic targets and diagnostic biomarkers for bone and joint diseases, such as osteoporosis, osteonecrosis, osteoarthritis, and delayed fracture healing.
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