一氧化氮
体内
血管生成
超氧化物
化学
血小板
药理学
环氧合酶
心肌梗塞
体外
激进的
医学
酶
生物化学
免疫学
内科学
生物
生物技术
有机化学
作者
Tohru Yamamoto,Richard J. Bing
出处
期刊:Proceedings of the Society for Experimental Biology and Medicine
[Wiley]
日期:2000-12-01
卷期号:225 (3): 200-206
被引量:116
标识
DOI:10.1046/j.1525-1373.2000.22525.x
摘要
Nitric oxide (NO) donors are pharmacologically active substances that release NO in vivo or in vitro. NO has a variety of functions such as the release of prostanoids, inhibition of platelet aggregation, effect on angiogenesis, and production of oxygen free radicals. This report discusses the chemical and pharmacological characteristics of NO donors, their effect on platelet function and cyclooxygenase, their cardiac action including myocardial infarction, and release of superoxide anions. This review stresses NO tolerance and the effect of NO donors on angiogenesis in myocardial infarction and in solid tumors.
科研通智能强力驱动
Strongly Powered by AbleSci AI