卫星
再生医学
生物
干细胞
祖细胞
心肌细胞
再生(生物学)
细胞生物学
骨骼肌
肌发生
人口
神经科学
解剖
医学
环境卫生
航空航天工程
工程类
作者
Shihuan Kuang,Michael A. Rudnicki
标识
DOI:10.1016/j.molmed.2007.12.004
摘要
Adult skeletal muscle contains an abundant and highly accessible population of muscle stem and progenitor cells called satellite cells. The primary function of satellite cells is to mediate postnatal muscle growth and repair. Owing to their availability and remarkable capacity to regenerate damaged muscle, satellite cells and their descendent myoblasts have been considered as powerful candidates for cell-based therapies to treat muscular dystrophies and other neuromuscular diseases. However, regenerative medicine in muscle repair requires a thorough understanding of, and the ability to manipulate, the molecular mechanisms that control the proliferation, self-renewal and myogenic differentiation of satellite cells. Here, we review the latest advances in our current understanding of the quiescence, activation, proliferation and self-renewal of satellite cells and the challenges in the development of satellite cell-based regenerative medicine.
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