A Study on Sonodynamic Therapy-Antitumor Effect of Novel Sonodynamic Compounds under Ultrasound

Diacetylhematoporphyrin-mitomycin C conjugate( diAc-Hp-MMC ) ( 1 ) prepared by a condensation of diacetylhematoporphyrin with MMC in the presence of N, Ndimethylaminopyridine and dicyclohexylcarbodiimide, and two of the pyridocarbazole derivatives ( 8) and ( 9 ) were provided for sonodynamic compounds and these wmpounds were found to show excellent cell-killing effect, comparing to those of the known sonodynamc compound hematoporphyrin, Hp 2HC1 ( 2).Di-Ac-Hp ( 3 ), Hp-Co ( 4).Hp-Fe (5 ), Acrinol ( 6 )and MMC ( 7 ).