SELDI Protein Chip Technology for the Detection of Serum Biomarkers for Liver Disease

The need to identify disease biomarkers is critical to ensure fast diagnosis and timely treatment. Surface enhanced laser desorption/ionization time-of-fight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery. This short review provides an overview of how it functions and also describes its advantages and drawbacks. Keywords: Surface enhanced laser desorption/ionization, proteomics, biomarker, liver diseases