对称化
对映选择合成
阿托品
化学
酶
醛
氧化酶试验
立体化学
生物催化
有机化学
组合化学
催化作用
反应机理
作者
Bo Yuan,Abigail Page,Christopher P. Worrall,Franck Escalettes,Simon C. Willies,Joseph J. W. McDouall,Nicholas J. Turner,Jonathan Clayden
标识
DOI:10.1002/anie.201002580
摘要
All roads lead to …︁ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme).
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