血管活性肠肽
医学
P物质
内科学
降钙素
内分泌学
生理盐水
神经激肽A
血管活性
降钙素基因相关肽
神经肽
受体
作者
Catherine Smith,Beryl A. Atkinson,Richard W Morris,N.A. Hayes,J. C. Foreman,T H Lee
出处
期刊:The Lancet
[Elsevier]
日期:1992-01-01
卷期号:339 (8785): 91-93
被引量:34
标识
DOI:10.1016/0140-6736(92)91000-x
摘要
Cutaneous wheal and flare responses to increasing concentrations of calcitonin gene-related peptide, substance P, neurokinin A, vasoactive intestinal polypeptide (VIP), compound 48/80, and phosphate-buffered saline were measured in 10 patients with chronic idiopathic urticaria and 10 healthy controls. A significant increase in VIP-induced wheal, but not flare or cutaneous blood flow, was seen in urticarial patients compared with controls (p less than 0.001). No significant differences in responses to other tested compounds were found between these groups. These data point to an increased sensitivity of microvasculature to VIP in patients with chronic idiopathic urticaria.
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