Self-Assembly of Bidentate Ligands for Combinatorial Homogeneous Catalysis:  Asymmetric Rhodium-Catalyzed Hydrogenation

The first chiral ligand library based on self-assembly through complementary hydrogen-bonding was realized. From a 10 x 4 ligand library, catalysts that show excellent activity and enantioselectivity for the asymmetric rhodium-catalyzed hydrogenation have been identified.