“POM-Lock” nanozymes serve as chirality-keyed bacterial membrane disruptors and wound repair agents for chemodynamic therapy

redox cycling and the highly efficient membrane penetration enabled by chiral matching. Crucially, the "lock-and-key" mechanism allows L-POM to selectively disrupt bacterial membrane integrity while promoting fibroblast migration. In an infected wound model, wounds treated with L-POM achieved near-complete closure by day 10. Comprehensive biosafety evaluations revealed negligible hemolytic activity and organ toxicity. This work not only overcomes the limitation of insufficient targeting specificity in conventional POM materials but also establishes a paradigm for developing chiral nanozymes with precision antibacterial functionality.