Juvenile Toxicity Study Design for the Rodent and Rabbit

Chapter 9 Juvenile Toxicity Study Design for the Rodent and Rabbit Alan M. Hoberman, Alan M. Hoberman Research Department, Charles River Laboratories Preclinical Services, Horsham, PA, USASearch for more papers by this authorJohn F. Barnett, John F. Barnett Neurobehavioral Toxicology Department, Charles River Laboratories Preclinical Services, Horsham, PA, USASearch for more papers by this author Alan M. Hoberman, Alan M. Hoberman Research Department, Charles River Laboratories Preclinical Services, Horsham, PA, USASearch for more papers by this authorJohn F. Barnett, John F. Barnett Neurobehavioral Toxicology Department, Charles River Laboratories Preclinical Services, Horsham, PA, USASearch for more papers by this author Book Editor(s):Alan M. Hoberman, Alan M. Hoberman Research Department, Charles River Laboratories Preclinical Services, Horsham, PA, USASearch for more papers by this authorElise M. Lewis, Elise M. Lewis Elise M. Lewis, Reproductive and Neurobehavioral Toxicology, Charles River Preclinical Services, Horsham, PA, USASearch for more papers by this author First published: 11 January 2012 https://doi.org/10.1002/9781118168226.ch9Citations: 4 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary This chapter contains sections titled: Purpose Introduction General Considerations Regarding Toxicology Studies Conducted for Submission to Regulatory Agencies Collection of Pharmacodynamic and Kinetic Data (PK/TK) for Dosage Selection The Timing of First Exposure When to Use Mice, Rats, or Rabbits Route and Method of Administration Group Sizes and Selection of Animals for Study Identification of Animals Growth and Development Parameters for Evaluation Feed Consumption Clinical Pathology Cholinesterase Assessments Physical Landmarks Nipple Evaluation Sexual Maturation Behavioral Evaluations Reproduction Functional Immunotoxicity Evaluations Acknowledgments References Citing Literature Pediatric Nonclinical Drug Testing: Pediatric Nonclinical Drug Testing: Principles, Requirements, and Practices RelatedInformation