Cosmeceutical are a unique category of skin care products offering added therapeutic benefits to consumers. The use of cosmeceuticals is now an integral part of any treatment armamentarium for patients desiring skin rejuvenation. Physician practicing aesthetic medicine should be familiar with commonly used cosmeceuticals and have an understanding of science behind their use. This chapter will discuss the cosmeceutical marketplace and the evolving role of these unique skin care products in the treatment of cosmetic patients. The regulatory issues surrounding cosmeceuticals will also be discussed.