Multi-component exercise training improves the physical and cognitive function of the elderly with mild cognitive impairment: a six-month randomized controlled trial

医学 蒙特利尔认知评估 物理疗法 认知 随机对照试验 认知障碍 干预(咨询) 方差分析 认知训练 内科学 精神科
作者
Lan Li,Mengjiao Liu,Hui Zeng,Lü Pan
出处
期刊:Annals of palliative medicine [AME Publishing Company]
卷期号:10 (8): 8919-8929 被引量:32
标识
DOI:10.21037/apm-21-1809
摘要

Background: This study explored the effects of multi-component exercise training on the physical and cognitive function of the elderly with mild cognitive impairment (MCI). Methods: A total of 90 older adults with MCI were chosen from screened volunteers and randomly assigned into 2 groups (n=45), and 84 completed the 6-month follow-up. Participants in the control group received general community health instruction, while the multi-component exercise training performed on the other group. The multi-component exercise training performed on these participants was designed to suit Chinese elderly based on advice from the nursing specialist and sports medicine specialist after the preliminary experiment. The Chinese version Mini-Physical Performance Test (CM-PPT), the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA) scores were examined by repeated measures analysis of variance to evaluate the physical and cognitive function of adults with MCI before and at 3 and 6 months after the intervention. The follow-up data collectors were blinded to group allocation. P<0.05 was considered statistically significant. Results: (I) The average score of CM-PPT was increased from 11.36±2.69 to 11.88±2.40 and 12.83±2.19 in 3 and 6 months respectively after intervention, while control group was decreased from 10.79±2.73 to 10.24±2.62 in 3 months and 9.21±2.09 in 6 months. CM-PPT scores with the main intervention effect and the interaction between intervention and time were both statistically significant (P<0.05), indicating that the physical function of participants with MCI were improved after intervention. (II) The average score of MoCA was increased from 21.52±2.05 to 23.48±1.47 (3 months) and 25.19±1.29 (6 months) after intervention, while control group was decreased from 21.14.79±1.97 to 20.21±1.88 and 19.45±2.00 in 3 and 6 months. The score of MMSE showed the same trend with the score of MoCA. The MoCA score with main intervention effect and the MMSE and MoCA scores with the effect of time, the MMSE and MoCA scores with the interaction between the intervention and time were all statistically significant (P<0.05), showing that the cognitive function of participants with MCI was improved by the intervention. Conclusions: Multi-component exercise training could significantly improve physical function and cognitive function of the elderly with MCI. Trial Registration: Chinese Clinical Trial Registry ChiCTR2100049350.
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