This chapter evaluates the properties of the most commonly employed wound closure materials in pediatric dermatologic surgery. Sutures are the most commonly used wound closure material in dermatologic surgery. There are now over 5000 different types including a myriad of suture materials and needles, staples, topical adhesives, tapes, and more. Each suture material has unique features that influence suture strength, workability, and potential for complications. Suture selection is guided by the anatomic location and individual wound characteristics. Suture related complications are generally due to improper suture placement or due to tissue reactivity. Absorbable sutures are primarily use for buried stitches in a layered closure; though in pediatric dermatologic surgery they may offer advantages for both deep and superficial sutures. Non-absorbable sutures are primarily used as superficial sutures in a layered closure or for simple full-thickness repair of a smaller defect.