白杨素
蜂胶
药理学
医学
体内
神经退行性变
生物利用度
疾病
化学
传统医学
生物
抗氧化剂
生物技术
生物化学
内科学
类黄酮
作者
Monika Stompor-Gorący,Agata Bajek-Bil,Maciej Machaczka
出处
期刊:Nutrients
[MDPI AG]
日期:2021-06-14
卷期号:13 (6): 2038-2038
被引量:55
摘要
Chrysin belongs to the group of natural polyphenols. It can be found, among others, in honey, propolis and fruits and has a wide range of biological activities, including the prevention of oxidative stress, inflammation, neurodegeneration and carcinogenesis. Being a part of the human diet, chrysin is considered to be a promising compound to be used in the prevention of many diseases, including cancers, diabetes and neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Nevertheless, due to the low solubility of chrysin in water and under physiological conditions, its bioavailability is low. For this reason, attempts at its functionalization have been undertaken, aiming to increase its absorption and thus augment its in vivo therapeutic efficacy. The aim of this review is to summarize the most recent research on chrysin, including its sources, metabolism, pro-health effects and the effects of its functionalization on biological activity and pharmacological efficacy, evaluated both in vitro and in vivo.
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