神经科学
神经病理性疼痛
神经营养因子
脑源性神经营养因子
神经营养素
脊髓
伤害
突触可塑性
神经传递
医学
心理学
内科学
受体
作者
Wu Zhou,Zhiping Xie,Chengcai Li,Zelong Xing,Shenke Xie,Meihua Li,Jian Yao
标识
DOI:10.1016/j.neulet.2021.135965
摘要
Neuropathic pain (NP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. The mechanisms underlying the onset and persistence of NP are unclear. Therefore, research concerning these mechanisms has become an important focus in the medical field. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling molecules. BDNF is an important regulator of neuronal development, synaptic transmission, and cellular and synaptic plasticity, which are essential for nerve maintenance and repair. However, BDNF is upregulated in the spinal dorsal horn and can promote NP by activating glial cells, reducing inhibitory functions and enhancing excitement after nociceptive stimulation. This review considers the relationship between NP and BDNF signaling in the spinal dorsal horn and discusses potentially related pathological mechanisms.
科研通智能强力驱动
Strongly Powered by AbleSci AI