胶束
赫拉
阿霉素
化学
细胞毒性
磷酰胆碱
药物输送
动态光散射
共轭体系
生物物理学
核化学
纳米颗粒
材料科学
体外
聚合物
有机化学
纳米技术
生物化学
水溶液
生物
化疗
遗传学
作者
Qian Lu,Meijun Yi,Mengchen Zhang,Zhangyu Shi,Shiping Zhang
出处
期刊:Langmuir
[American Chemical Society]
日期:2018-12-19
卷期号:35 (2): 504-512
被引量:25
标识
DOI:10.1021/acs.langmuir.8b03693
摘要
Tumor-targeting nano-drug-delivery systems hold great potential to improve the therapeutic efficacy and alleviate the side effects of cancer treatments. Herein, folic acid (FA)-decorated amphiphilic copolymer of FA-P(MPC-co-MaPCL) (MPC: 2-methacryloxoethyl phosphorylcholine, MaPCL: poly(ε-caprolactone) macromonomer) is synthesized and its micelles are fabricated for doxorubicin (DOX) delivery. And non-FA-decorated P(MPC-co-MaPCL) micelles are used as the control. Dynamic light scattering and scanning electron microscopy measurements reveal that FA-P(MPC-co-MaPCL) and P(MPC-co-MaPCL) micelles are spherical with average diameters of 140 and 90 nm, respectively. The evaluation in vitro demonstrates that the blank micelles are nontoxic, while DOX-loaded FA-P(MPC-co-MaPCL) micelles show significant cytotoxicity to HeLa cells and slight cytotoxicity to L929 cells. Moreover, the cellular uptake of DOX-loaded FA-P(MPC-co-MaPCL) micelles in HeLa cells are 4.3-fold and 1.7-fold higher than that of DOX-loaded P(MPC-co-MaPCL) micelles and free DOX after 6 h of incubation, respectively. These results indicate the great potential of this system in anticancer target drug-delivery applications.
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