三氯异氰尿酸
化学
催化作用
试剂
反应性(心理学)
电泳剂
亮绿色
有机化学
组合化学
医学
病理
替代医学
作者
David A. Rogers,Adam T. Bensalah,Alvaro Tomas Espinosa,John L. Hoerr,Fares H. Refai,Amy K. Pitzel,Juan José Alvarado,Angus A. Lamar
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-05-29
卷期号:21 (11): 4229-4233
被引量:32
标识
DOI:10.1021/acs.orglett.9b01414
摘要
Heteroarenes and arenes that contain electron-withdrawing groups are chlorinated in good to excellent yields (scalable to gram scale) using trichloroisocyanuric acid (TCCA) and catalytic Brilliant Green (BG). Visible-light activation of BG serves to amplify the electrophilic nature of TCCA, providing a mild alternative approach to acid-promoted chlorination of deactivated (hetero)aromatic substrates. The utility of the TCCA/BG system is demonstrated through comparison to other chlorinating reagents and by the chlorination of pharmaceuticals including caffeine, lidocaine, and phenazone.
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