痤疮丙酸杆菌
痤疮
角质形成细胞
MAPK/ERK通路
炎症
信号转导
生物
医学
免疫学
皮肤病科
细胞生物学
体外
生物化学
作者
Nuo Xu,Wenjuan Deng,Gaiying He,Xiaoshuang Gan,Shuang Gao,Yu Chen,Yitian Gao,Ke Xu,Junmei Qi,Hao-jie Lin,Ли Шен,Xiaokun Li,Zhenlin Hu
标识
DOI:10.1080/08923973.2018.1519831
摘要
Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and skin inflammation. Mangostins are well-known for their anti-bacterial and anti-inflammatory effects, suggesting that mangostins may have therapeutic potential for acne. The present study aimed to explore the anti-acne effects of mangostins from the perspective of multiple pathogenic mechanisms of acne.Methods: The effects of α- and γ-mangostins on the growth of P. acnes and lipase activity were analyzed. Their effects on P. acnes-induced keratinocyte proliferation were examined by CCK-8. The expression of inflammatory genes and activation of NF-κB and MAPK signaling pathways were detected by quantitative real-time PCR and western blotting, respectively.Results: Alpha- and γ-mangostins not only inhibited the growth of P. acnes, but also reduced the proliferation of keratinocytes induced by heat-killed P. acnes. Furthermore, α- and γ-mangostins were able to suppress P. acnes-induced expression of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 in keratinocytes by inhibiting the activation of NF-κB and MAPK signaling pathways.Discussion and conclusions: Mangostins appeared to possess multiple anti-acne activities, including the inhibition of P. acnes growth, regulation of keratinocytes proliferation, and attenuation of skin inflammatory reaction. Hence, mangostins might be developed into a potential therapeutic agent for the treatment of acne.
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