异型性
尿路上皮癌
医学
免疫组织化学
病理
发育不良
原位癌
临床意义
核异型性
泌尿生殖系统
癌
癌症
内科学
膀胱癌
出处
期刊:Pathology
[Elsevier]
日期:2021-01-01
卷期号:53 (1): 86-95
被引量:8
标识
DOI:10.1016/j.pathol.2020.10.001
摘要
Summary
Based on the current WHO 2016 classification, the spectrum of flat urothelial lesions with atypia includes reactive urothelial atypia, urothelial atypia of unknown significance, urothelial dysplasia, and urothelial carcinoma in situ (CIS). Classification along this continuous spectrum of atypia can be one of the most challenging areas in all genitourinary pathology. This review will focus on the diagnosis of urothelial CIS in routine clinical practice, emphasising histological criteria, histological spectrum (i.e., ‘variant' types), adjunctive immunohistochemistry, intraoperative evaluation, and distinction from its morphological mimics.
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