Wearable Iontophoresis Device Using Stretchable Electrodes Towards Transdermal Delivery

In this study, a wearable iontophoresis device towards transdermal delivery of anticancer vaccination was developed. The stretchable electrodes and flexible PCB(printed circuit board) were taken advantage of in this device to improve the contact between a sensor and body. Iontophoresis via small electronic current is technology for transdermal drug delivery. Electronic current during iontophoresis expands junctions between cells and enables transdermal administration of drugs by electrostatic repulsion and electroosmotic flow. In this study, wearable iontophoresis device composed of flexible polyimide substrate and disposable stretchable electrodes was developed. The electrodes promote the adhesion to the skin and are expected to improve the efficiency of transdermal delivery. The current value between electrodes can be controlled by a smartphone via Bluetooth. These technologies will realize the precise administration of drug for patient and doctors.