Psychological, social and everyday visual impact of diabetic macular oedema and diabetic retinopathy: a systematic review

Abstract Aims To synthesize the evidence on the impact of diabetic retinopathy and diabetic macular oedema from the patient perspective. Methods A systematic literature review was conducted using MEDLINE Complete, PsycINFO, EMBASE and AMED. We included articles investigating the impact of the condition on quality of life, symptoms, visual functioning, activities of daily living, well‐being, social functioning, and financial status. The studies evaluated were observational, including cross‐sectional, prospective cohort and retrospective cohort designs. Outcome data were extracted and synthesized. Results Searches yielded 5114 publications. After screening, 85 studies were included, measuring the following outcomes: visual functioning ( n =46); quality of life ( n =22); well‐being ( n =16); functional status ( n =5); work ( n =4); and visual task performance ( n =2). Diabetic retinopathy has a considerable impact on visual functioning and this is greater in people with greater disease severity. Diabetic retinopathy significantly limits activities including working, driving, walking and reading, and has the potential to have a negative impact on psychological well‐being. Conclusions Diabetic retinopathy is associated with poor self‐reported visual functioning, well‐being, and health‐related quality of life. Ability to perform basic everyday tasks appears to diminish with disease severity. Some studies suggest impaired mobility and problems with work, but there are gaps in this evidence.