高尿酸血症
黄嘌呤氧化酶
尿酸
痛风
药理学
化学
炎症体
肽
止痛药
医学
生物化学
酶
受体
作者
Naixin Liu,Ying Wang,Lin Zeng,Saige Yin,Yan Hu,Shanshan Li,Yang Fu,Xin-Ping Zhang,Chun Xie,Longjun Shu,Yilin Li,Honghong Sun,Meifeng Yang,Jing Sun
标识
DOI:10.1021/acs.jafc.0c02535
摘要
Gout and hyperuricemia can seriously affect the quality of life; at present, however, existing medicines are unable to meet all clinical needs. In the current study, a novel peptide (i.e., rice-derived-peptide-3 (RDP3), AAAAMAGPK-NH2, 785.97 Da) in water extract obtained from shelled Oryza sativa fruits was identified. Testing revealed that RDP3 (minimum effective concentration 100 μg/kg) did not show both hemolytic and acute toxicity, and reduced uric acid levels in the serum of hyperuricemic mice by inhibiting xanthine oxidase activity and decreasing urate transporter 1 expression. RDP3 also alleviated renal injury in hyperuricemic mice by decreasing NLRP3 inflammasome expression. Furthermore, RDP3 alleviated formalin-induced paw pain and reduced monosodium urate crystal-induced paw swelling and inflammatory factors in mice. Thus, this newly identified peptide reduced uric acid levels and renal damage in hyperuricemic mice and showed anti-inflammatory and analgesic activities, indicating the potential of RDP3 as an antigout medicine candidate.
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