非人灵长类
非人灵长类
猕猴
狐猴
人体回声定位
细胞生物学
作者
Makoto Hosoya,Masato Fujioka,Ayako Y. Murayama,Hideyuki Okano,Kaoru Ogawa
出处
期刊:FEBS Journal
[Wiley]
日期:2021-01-01
卷期号:288 (1): 325-353
被引量:2
摘要
Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate-specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
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