Selective detection of peroxynitrite in living cells by a near-infrared diphenyl phosphinate-based dicyanoisophorone probe

Abstract A new NIR fluorescent probe for detection of ONOO− has been developed, which possesses a large Stokes shift, good selectivity and low cytotoxicity. This NR-ONOO probe exhibits a strong turn-on near-infrared fluorescence response toward ONOO− ion under excitation at 560 nm and has been successfully applied in detecting ONOO− in living HeLa cells.