自愈水凝胶
明胶
生物相容性
伤口愈合
壳聚糖
极限抗拉强度
聚乙烯醇
活力测定
生物医学工程
MTT法
体内
化学
材料科学
体外
复合材料
高分子化学
外科
医学
生物技术
生物化学
生物
冶金
作者
Amir Shamloo,Zahra Aghababaie,Homa Afjoul,Mehrzad Jami,Mina Razaghzadeh Bidgoli,Manouchehr Vossoughi,Ahmad Ramazani,Kambiz Kamyab‐Hesari
标识
DOI:10.1016/j.ijpharm.2020.120068
摘要
In this study, physically cross-linked hydrogels were developed by freezing-thawing method while different concentrations of honey were included into the hydrogels for accelerated wound healing. The hydrogel was composed of chitosan, polyvinyl alcohol (PVA), and gelatin with the ratio of 2:1:1 (v/v), respectively. Further, the effect of honey concentrations on antibacterial properties, and cell behavior was investigated. In vivo studies, including wound healing mechanism using rat model and histological analysis of section tissue samples were performed. The results illustrated that the incorporation of honey in hydrogels increased the ultimate strain of hydrogels approximately two times, while reduced the ultimate tensile strength and elastic modulus of hydrogels. Moreover, the antibacterial activities of samples were increased by increasing the concentration of honey. Regarding MTT assay, as the concentration of honey increased, the cell viability of hydrogels was enhanced until an optimal amount of honey. Further, the integration of honey into the hydrogel matrix results in the maintenance of a well-structured layer of epidermis containing mature collagen and accelerates the rate of wound healing. The 3D Chitosan/PVA/Gelatin hydrogel containing honey with appropriate mechanical, antibacterial activity, and biocompatibility could be a promising approach for wound healing.
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