内侧前脑束
神经科学
前脑
前额叶皮质
心理学
扣带回前部
磁共振弥散成像
解剖
医学
磁共振成像
认知
中枢神经系统
纹状体
放射科
多巴胺
作者
Volker A. Coenen,Jaak Panksepp,Trevor A. Hurwitz,Horst Urbach,Burkhard Mädler
出处
期刊:Journal of Neuropsychiatry and Clinical Neurosciences
[American Psychiatric Association Publishing]
日期:2012-01-01
卷期号:24 (2): 223-236
被引量:296
标识
DOI:10.1176/appi.neuropsych.11080180
摘要
The medial forebrain bundle (MFB), a key structure of reward-seeking circuitry, remains inadequately characterized in humans despite its vast importance for emotional processing and development of addictions and depression. Using Diffusion Tensor Imaging Fiber Tracking (DTI FT) the authors describe potential converging ascending and descending MFB and anterior thalamic radiation (ATR) that may mediate major brain reward-seeking and punishment functions. Authors highlight novel connectivity, such as supero-lateral-branch MFB and ATR convergence, caudally as well as rostrally, in the anterior limb of the internal capsule and medial prefrontal cortex. These anatomical convergences may sustain a dynamic equilibrium between positive and negative affective states in human mood-regulation and its various disorders, especially evident in addictions and depression.
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