Pharmacokinetics of Lidocaine Via Epidural Injetion in Patients With Hepatic Dysfunction

OBJECTIVE:To study the pharmacokinetics of lidocaine via epidural injection in patients with mild hepatic dysfunction.METHODS:The blood concentration of lidocaine was determined by polarized fluorescence immuno-assay,rapid blood drug concentration detector(TDx)and kit.RESULTS:The pharmacokinetic parameters could be described as one-compartment model.CONCLUSION:The pharmacokinetics of lidocaine via epidural injection in patients with mild hepatic dysfunction is comparable with that in subjects with normal liver function.