The paper explains the reaction mechanism about MDEA aqueous solution and MDEA-Sulfolane solution with acid gas, compares their selectivities, and discusses the detail application of MDEA-Sulfolane solution. The focal point is the equilibrium selectivity mechanism and application of MDEA-Sulfolane solution. The paper suggests solving over-loading problem of Purification Plant of Northwest Sichuan by improving selectivity using MDEA-Sulfolane solution.