The expression and significance of IL-6 in intracerebral hemorrhage

Objective:To investigate the expression of IL-6 in intracerebral hemorrhage (IHC) and to find out its significance and its correlation with the time of intracerebral hemorrhage.Methods:The expression of IL-6 was assessed by immunohistochemistry staining.Results:In 65 cease of intracerebral hemorrhage, positive expression rate of IL-6 was 92.3% (60/65) and 10%(1/10) in normal brain tissues.The positive rate was significantly higher in intracerebral hemorrhage than in normal brain tissues(P0.01).IL-6 positive expression rate was 91.5%(43/47) in 24 hours,and 94.4%(17/18) after 24 hours of intracerebral hemorrhage.IL-6 expression was irrelated with time of operation after intracerebral hemorrhage (P0.05).Conclusion: IL-6 may be involved in the pathophysiologic process of brain edema after ICH brain edema, after ICH leads to the change of concentrations of IL-6 and aggravate brain damage around the hematoma.