Recent advances in antibody technique(1):Humanized antibody technique

In the past 100 years,antibody has played a significant role in human disease diagnosis and treatment and the analysis of detrimental substances.Especially,the inventions of both monoclonal antibody technique in 1975 and genetic engineering technique in 1986,on one hand,have made it possible for producing abundant antibodies of high specificity and homogeneity,on the other hand,help chimeric antibody and fully human antibody bring benefit to human beings.To overcome the problem that murine monoclonal antibody may induce HAMA,technologies such as chimeric antibody,reshaping antibody,small-molecule antibody and improvements of the specificity between antibody and antigen have become the main trend when developing antibody technique.This review gives an overview on antibody humanization,small-molecule antibody and composite function of antibody.