Allosteric Effects: Binding Cooperativity in a Subunit Model

The macrobicyclic polyether (1) is the first “small” model system which exhibits a binding cooperativity. It could be shown by 600-MHz 1H-NMR studies that binding of one Hg(CN)2 to (1) increases its binding ability for a second Hg(CN)2 by a factor of ten.