化学
荧光
变构调节
虚拟筛选
荧光各向异性
变构调节剂
维甲酸
转录因子
生物物理学
功能（生物学）
药物发现
计算生物学
受体
生物化学
细胞生物学
基因
物理
量子力学
膜
生物
作者
Yan‐Cheng Yu,Zhen‐Jiang Tong,Xiaoting Liang,Jiazhen Wu,Yujing Xu,Jingjing Wang,Mengyuan Zhang,Tian‐Hua Wei,Jin Yang,Yibo Wang,Qing-Xin Wang,Qingqing Li,Zixuan Wang,Xuejiao Leng,Ning Ding,Xin Xue,Shan‐Liang Sun,Nian‐Guang Li,Xiao-Long Wang
标识
DOI：10.1021/acs.jmedchem.4c00058
摘要
Retinoic acid receptor-related orphan receptor γ (RORγ) acts as a crucial transcription factor in Th17 cells and is involved in diverse autoimmune disorders. RORγ allosteric inhibitors have gained significant research focus as a novel strategy to inhibit RORγ transcriptional activity. Leveraging the high affinity and selectivity of RORγ allosteric inhibitor
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