化学
互变异构体
吗啉
异构化
哌嗪
戒指(化学)
氮气
计算化学
有机化学
催化作用
作者
Junhe Ma,Qingmei Ye,Rebecca A. Green,John A. Gurak,Sloan Ayers,Yande Huang,Scott A. Miller
摘要
Abstract This study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring.
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