Exploring the structures and molecular mechanisms of bioactive compounds from marine foods for hyperuricemia prevention: a systematic review

Hyperuricemia, characterized by an elevation in serum uric acid (UA) levels, stands as a significant metabolic ailment threatening human well-being. Presently, dietary adjustments have become a crucial strategy in managing serum UA levels among individuals grappling with hyperuricemia and gout. Given its unique ecosystem, the ocean hosts a plethora of organisms boasting distinct structures and active components. The marine bioactive substances, such as bioactive peptides, polysaccharides, lipids, and small molecules, have garnered attention in the research and development of modern functional foods and biomedicine due to their profound efficacy and distinctive compositions. Notably, the functional components of marine foods have been studied for their potential in preventing hyperuricemia. However, the precise molecular mechanism underlying their actions remain incompletely elucidated. This review article highlights the diversity of marine active compounds and the latest progress in understanding urate-lowering mechanism. Principal mechanisms primarily encompass the regulation of UA metabolism, maintenance of intestinal homeostasis, mitigation of inflammatory responses, and alleviation of oxidative stress. Furthermore, we scrutinized the constraints of prior studies and provided recommendations. In sum, this article furnished a valuable resource concerning the intervention of bioactive compounds sourced from marine foods in the context of hyperuricemia.