Dual Photoredox/Copper-Catalyzed Radical cis-Selective Allylic Trifluoromethylation

We herein report a dual visible-light photoredox- and copper-catalyzed Z -selective allyl trifluoromethylation reaction of allylamine by using trifluoromethylpyridinium salt (TFSP) as the trifluoromethyl radical precursor. Various thermodynamically disfavorable allyl trifluoromethylated cis -enamides were accessible with moderate to good isolated yields. Cuprous oxide or copper nanoclusters were crucial as the co-catalyst for this transformation.