Three Calcium Hydroxylapatite‐Based Dermal Fillers Marketed in Mexico: Comparison of Particle Size and Shape Using Electron Microscopy

Dermal fillers have been a popular choice for cosmetic dermatology procedures, and understanding the physical properties of microparticles used in dermal fillers is crucial for developing safe and effective aesthetic treatments. This study analyzed three dermal filler products (Radiesse, HarmonyCA, and Hydroxyfill) based on calcium hydroxyapatite microspheres approved for dermal filler procedures in Mexico. The study used scanning electron microscopic analysis to study the morphology and characteristics of the calcium hydroxyapatite microspheres used in these dermal filler products. Results revealed important differences in the shape of the microspheres between the three products, which may have implications for their biocompatibility and performance in clinical use. Gaining a deeper understanding of these differences enables the improved development of dermal fillers to meet the growing demand for safe and effective aesthetic treatments. This study contributes to building knowledge about the use of microparticles in soft tissue fillers for aesthetic treatments and medical applications.