GPX4
平衡
细胞凋亡
败血症
医学
生物
免疫学
癌症研究
氧化应激
细胞生物学
谷胱甘肽过氧化物酶
内科学
遗传学
超氧化物歧化酶
作者
Wangzheqi Zhang,Yang Liu,Lianshan Yan,Cheng Zhu,Zhiqiang Zou
标识
DOI:10.1016/j.biopha.2024.116512
摘要
GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in maintaining the redox homeostasis within the body. Ferroptosis, a form of iron-dependent non-apoptotic cell death, has gained considerable attention in recent years due to its involvement in multiple pathological processes. GPX4 is closely associated with ferroptosis and functions as the primary inhibitor of this process. Together, GPX4 and ferroptosis contribute to the pathophysiology of several diseases, including sepsis, nervous system diseases, ischemia reperfusion injury, cardiovascular diseases, and cancer. This review comprehensively explores the regulatory roles and impacts of GPX4 and ferroptosis in the development and progression of these diseases, with the aim of providing insights for identifying potential therapeutic strategies in the future.
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