化学
生物标志物
异质结
纳米技术
灵敏度(控制系统)
光电子学
生物化学
材料科学
工程类
物理
电子工程
作者
Qing-Ying Ai,Ben-Fang Xu,Fuzong Xu,Aijun Wang,Li-Ping Mei,Liang Wu,Pei Song,Jiu‐Ju Feng
出处
期刊:Talanta
[Elsevier]
日期:2024-07-01
卷期号:274: 126034-126034
标识
DOI:10.1016/j.talanta.2024.126034
摘要
As an important prognostic indicator in breast cancer, human epithelial growth factor receptor-2 (HER-2) is of importance for assessing prognosis of breast cancer patients, whose accurate and facile analysis are imperative in clinical diagnosis and treatment. Herein, photoactive Z-scheme UiO-66/CdIn2S4 heterojunction was constructed by a hydrothermal method, whose optical property and photoactivity were critically investigated by a range of techniques, combined by elucidating the interfacial charge transfer mechanism. Meanwhile, PtPdCu nanoflowers (NFs) were fabricated by a simple aqueous wet-chemical method, whose peroxidase (POD)-mimicking catalytic activity was scrutinized by representative tetramethylbenzidine (TMB) oxidation in H2O2 system. Taken together, the UiO-66/CdIn2S4 based photoelectrochemical (PEC) aptasensor was established for quantitative analysis of HER-2, where the detection signals were further magnified through catalytic precipitation reaction towards 4-chloro-1-naphthol (4-CN) oxidation (assisted by the PtPdCu NFs nanozyme). The PEC aptasensor presented a broader linear range within 0.1 pg mL−1–0.1 μg mL−1 and a lower limit of detection of 0.07 pg mL−1. This work developed a new ultrasensitive PEC aptasensor for quantitative determination of HER-2, holding substantial promise for clinical diagnostics.
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